全文获取类型
收费全文 | 26994篇 |
免费 | 2796篇 |
国内免费 | 14篇 |
出版年
2023年 | 116篇 |
2022年 | 98篇 |
2021年 | 581篇 |
2020年 | 351篇 |
2019年 | 420篇 |
2018年 | 503篇 |
2017年 | 509篇 |
2016年 | 780篇 |
2015年 | 1308篇 |
2014年 | 1384篇 |
2013年 | 1496篇 |
2012年 | 2044篇 |
2011年 | 2019篇 |
2010年 | 1342篇 |
2009年 | 1166篇 |
2008年 | 1600篇 |
2007年 | 1708篇 |
2006年 | 1342篇 |
2005年 | 1382篇 |
2004年 | 1390篇 |
2003年 | 1293篇 |
2002年 | 1218篇 |
2001年 | 379篇 |
2000年 | 359篇 |
1999年 | 333篇 |
1998年 | 334篇 |
1997年 | 203篇 |
1996年 | 148篇 |
1995年 | 154篇 |
1994年 | 173篇 |
1993年 | 143篇 |
1992年 | 217篇 |
1991年 | 214篇 |
1990年 | 171篇 |
1989年 | 172篇 |
1988年 | 160篇 |
1987年 | 163篇 |
1986年 | 152篇 |
1985年 | 176篇 |
1984年 | 176篇 |
1983年 | 128篇 |
1982年 | 102篇 |
1981年 | 130篇 |
1980年 | 105篇 |
1979年 | 103篇 |
1978年 | 107篇 |
1977年 | 75篇 |
1976年 | 87篇 |
1974年 | 92篇 |
1971年 | 75篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Prakash , U., E. S. Barghoorn , and R. A. Scott . (Harvard U., Cambridge, Mass.) Fossil wood of Robinia and Gleditsia from the Tertiary of Montana . Amer. Jour. Bot. 49(7): 692–696. Illus. 1962.—Fossil woods representing 2 genera of the Leguminosae, Robinia Linnaeus and Gleditsia Clayton, have been identified from Tertiary beds in southern Montana. These woods are noteworthy owing to their exceptionally fine structural preservation and from the standpoint of their paleogeographical distribution. Neither genus now lives in the region of Montana. 相似文献
32.
33.
Climatic forcing and larval dispersal capabilities shape the replenishment of fishes and their habitat‐forming biota on a tropical coral reef 下载免费PDF全文
Shaun K. Wilson Martial Depcyznski Rebecca Fisher Thomas H. Holmes Mae M. Noble Ben T. Radford Michael Rule George Shedrawi Paul Tinkler Christopher J. Fulton 《Ecology and evolution》2018,8(3):1918-1928
Fluctuations in marine populations often relate to the supply of recruits by oceanic currents. Variation in these currents is typically driven by large‐scale changes in climate, in particular ENSO (El Nino Southern Oscillation). The dependence on large‐scale climatic changes may, however, be modified by early life history traits of marine taxa. Based on eight years of annual surveys, along 150 km of coastline, we examined how ENSO influenced abundance of juvenile fish, coral spat, and canopy‐forming macroalgae. We then investigated what traits make populations of some fish families more reliant on the ENSO relationship than others. Abundance of juvenile fish and coral recruits was generally positively correlated with the Southern Oscillation Index (SOI), higher densities recorded during La Niña years, when the ENSO‐influenced Leeuwin Current is stronger and sea surface temperature higher. The relationship is typically positive and stronger among fish families with shorter pelagic larval durations and stronger swimming abilities. The relationship is also stronger at sites on the coral back reef, although the strongest of all relationships were among the lethrinids (r = .9), siganids (r = .9), and mullids (r = .8), which recruit to macroalgal meadows in the lagoon. ENSO effects on habitat seem to moderate SOI–juvenile abundance relationship. Macroalgal canopies are higher during La Niña years, providing more favorable habitat for juvenile fish and strengthening the SOI effect on juvenile abundance. Conversely, loss of coral following a La Niña‐related heat wave may have compromised postsettlement survival of coral dependent species, weakening the influence of SOI on their abundance. This assessment of ENSO effects on tropical fish and habitat‐forming biota and how it is mediated by functional ecology improves our ability to predict and manage changes in the replenishment of marine populations. 相似文献
34.
The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key physiological function of PTPN22 was to prevent naïve T cell activation and effector cell responses in response to low affinity antigens. PTPN22 also has a more general role in limiting T cell receptor-induced proliferation. Here we present new data emphasizing this dual function for PTPN22 in T cells. Furthermore, we show that T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. We discuss the implication of these findings for our understanding of the roles of PTPN22 in regulating T cell responses and in autoimmunity. 相似文献
35.
36.
37.
DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis
William H. Grainger Cristina Machón David J. Scott Panos Soultanas 《Nucleic acids research》2010,38(9):2851-2864
Initiation of bacterial DNA replication at oriC is mediated by primosomal proteins that act cooperatively to melt an AT-rich region where the replicative helicase is loaded prior to the assembly of the replication fork. In Bacillus subtilis, the dnaD, dnaB and dnaI genes are essential for initiation of DNA replication. We established that their mRNAs are maintained in fast growing asynchronous cultures. DnaB is truncated at its C-terminus in a growth phase-dependent manner. Proteolysis is confined to cytosolic, not to membrane-associated DnaB, and affects oligomerization. Truncated DnaB is depleted at the oriC relative to the native protein. We propose that DNA-induced oligomerization is essential for its action at oriC and proteolysis regulates its localization at oriC. We show that DnaB has two separate ssDNA-binding sites one located within residues 1–300 and another between residues 365–428, and a dsDNA-binding site within residues 365–428. Tetramerization of DnaB is mediated within residues 1–300, and DNA-dependent oligomerization within residues 365–428. Finally, we show that association of DnaB with the oriC is asymmetric and extensive. It encompasses an area from the middle of dnaA to the end of yaaA that includes the AT-rich region melted during the initiation stage of DNA replication. 相似文献
38.
The uptake of L-glutamate into BHK21-C13 cells in culture has been studied. This amino acid appears to be transported via a relatively high affinity, low capacity, Na+-dependent transport system capable of the rapid accumulation of substrate amino acids. Kinetic studies of the inhibition of L-glutamate uptake has provided information as to the substrate and the molecular configuration required for transport via the glutamate transport system. This system exhibited marked substrate specificity and was only capable of transporting L-glutamate and aspartate and certain closely related acidic amino acid analogues. 相似文献
39.
40.